Fig. 5
From: In silico design of MHC class I high binding affinity peptides through motifs activation map
The top row represents heatmap (a), boxplot (b) and seq2logo (c) of HLA-A*0201 allele’s new peptides with 9 lengths generated from the well-trained network while the bottom row represents heatmap (d), boxplot (e) and seq2logo (f) of 10-mer peptides generated using fine-tune method corresponding to same allele. In heatmap, the horizontal axis indicates the site of peptide and the vertical axis indicate each peptide from the testing dataset, each pixel denotes the contribution of a certain site on the certain peptide to its binding affinity, where the lighter color is, the more contribution it represents. In the boxplot, each box collects all the contribution of peptides in the certain site and find out the average contribution to the binding affinity. We believe the site is important to this length peptide’s binding affinity if only the average is greater than zero. And in sequence logos, on the vertical, the logo distribution intuitively depicts the amino acid frequencies on each site of the peptides