Table 9 The top enriched protein pathways in the specific modules of physical (P), functional (F) and combined (C) PPIN. Pathways are mapped using PANTHER Pathway database (http://www.pantherdb.org/pathway/)
From: Functional homogeneity and specificity of topological modules in human proteome
Network | Specific pathways of modules |
|---|---|
P | Inflammation mediated by chemokine and cytokine signalling pathway; gonadotropin-releasing hormone receptor pathway; Wnt signalling pathway; Integrin signalling pathway; CCKR signalling map; Heterotrimeric G-protein signalling pathway; Angiogenesis; PDGF signalling pathway; Apoptosis signalling pathway; EGF receptor signalling pathway |
P-weighted | Inflammation mediated by chemokine and cytokine signalling pathway; gonadotropin-releasing hormone receptor pathway; Wnt signalling pathway; Integrin signalling pathway; PDGF signalling pathway; Heterotrimeric G-protein signalling pathway; Angiogenesis; Apoptosis signalling pathway; CCKR signalling map; Angiogenesis; EGF receptor signalling pathway; FGF signalling pathway; Huntington disease; Cadherin signalling pathway; Alzheimer disease-presenilin pathway |
F | Inflammation mediated by chemokine and cytokine signalling pathway; gonadotropin-releasing hormone receptor pathway; Wnt signalling pathway; Integrin signalling pathway, CCKR signalling map; Angiogenesis; EGF receptor signalling pathway; Huntington disease; Alzheimer disease-presenilin pathway; TGF-beta signalling pathway; PDGF signalling pathway; Heterotrimeric G-protein signalling pathway; Nicotinic acetylcholine receptor signalling pathway |
F-weighted | Inflammation mediated by chemokine and cytokine signalling pathway; gonadotropin-releasing hormone receptor pathway; Wnt signalling pathway; Integrin signalling pathway, CCKR signalling map; Angiogenesis; EGF receptor signalling pathway; FGF signalling pathway; Heterotrimeric G-protein signalling pathway; PDGF signalling pathway; Huntington disease; Alzheimer disease-presenilin pathway; B-cell activation; Parkinson disease; Insulin/IGF pathway; Interleukin signalling pathway; Ionotropic glutamate receptor pathway; Mannose metabolism; Pyridoxal-5-phosphate biosynthesis; PDGF signalling pathway |
C | Inflammation mediated by chemokine and cytokine signalling pathway; gonadotropin-releasing hormone receptor pathway; Wnt signalling pathway; Integrin signalling pathway, CCKR signalling map; Angiogenesis; Heterotrimeric G-protein signalling pathway; EGF receptor signalling pathway; PDGF signalling pathway; Huntington disease; FGF signalling pathway; Apoptosis signalling pathway |
C-weighted | Inflammation mediated by chemokine and cytokine signalling pathway; gonadotropin-releasing hormone receptor pathway; Wnt signalling pathway; Integrin signalling pathway, CCKR signalling map; Angiogenesis; Heterotrimeric G-protein signalling pathway; EGF receptor signalling pathway; FGF signalling pathway; Cadherin signalling pathway |