Inverse similarity and reliable negative samples for drug side-effect prediction

BMC Bioinformatics

Table 2 Macro-averaging F1-score/precision/recall of four typical classifiers based on negative samples selected by the proposed negative sample selection method and randomly selected negative samples

Method	Classifier	Macro_ F1	Macro_P	Macro_R
ComNegative	KNN	0.800	0.728	0.772
ComRandom	KNN	0.619	0.598	0.651
ChemTarRandom	KNN	0.581	0.553	0.626
ComNegative	ELM	0.774	0.761	0.604
ComRandom	ELM	0.586	0.572	0.601
ChemTarRandom	ELM	0.572	0.561	0.585
ComNegative	SVM	0.898	0.938	0.861
ComRandom	SVM	0.655	0.670	0.642
ChemTarRandom	SVM	0.606	0.622	0.598
ComNegative	RBF	0.822	0.828	0.818
ComRandom	RBF	0.606	0.592	0.622
ChemTarRandom	RBF	0.571	0.561	0.583

ISSN: 1471-2105