Exploiting locational and topological overlap model to identify modules in protein interaction networks

BMC Bioinformatics

Table 4 Overrepresentation scores of cancer genes in HPRD

PIN	Module number	Cancer module ratio	ORS	Cancer gene ratio (number)
module size > = 10
GPIN	10	0.2	0	0 (0)
CLPIN	8	0.25	0.125	0.0133 (6)
TOPIN	51	0.4902	0.098	0.0399 (18)
LTOPIN	34	0.441	0.1765	0.0421 (19)
module size > = 5
GPIN	336	0.273	0.0504	0.0887 (40)
CLPIN	252	0.3004	0.0593	0.0931 (42)
TOPIN	376	0.3528	0.0504	0.1242 (56)
LTOPIN	355	0.3539	0.0702	0.1441 (65)

ORS Overrepresentation Score, Cancer module ratio The ratio of modules containing cancer genes, Cancer gene ratio The ratio of cancer genes over genes in cancer modules

ISSN: 1471-2105