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Table 1 Performance of pRANK and AMYCO approaches in the prediction of mutation impact upon the aggregation of the human prion-like protein hnRNPA2

From: AMYCO: evaluation of mutational impact on prion-like proteins aggregation propensity

  pRANK AMYCO
Sensitivity 0 1
Specificity 1 1
Precision 1
Accuracy 0.45 1
MCC 1
Mean % error −7.08 −1.25
Standard Deviation (%) 37.71 12.19
SEM (%) 8.04 2.44
Coefficient of Determination 0.152 0.882
P-value (two tailed test) 0.468 < 1.00E-08
Rho (ρ) 0.334 0.929
  1. The best performance according to each particular parameter is shown in bold. Details on the calculation of the different statistic parameters are provided in the Additional file 1