Fig. 4

Common super-enhancer domains are associated with the early establishment of 3D chromatin loops. a The schematic overview of calculated loop recovery rate (upper panel) and super-enhancer domain enrichment (lower panel). b Heatmaps showing mean enrichment value of super-enhancer domains called from HCT-116 cell line (upper two panels) and all samples (lower two panels) at 20 min after cohesin recovery in loop anchors (left panels) and loop domains (right panels). Empirical p-values were calculated through random expectation values based on 10,000 iterations (* p-value < 0.05, ** p-value < 0.01, *** p-value < 0.001). c Bar plots of super-enhancer domain enrichment in the top 10% fast recovery loops for each time point in loop anchors (left) and loop domains (right) (two-sample t-test, * p-value < 0.05, ** p-value < 0.01, *** p-value < 0.001). d Model diagram of modes of super-enhancer functions. Canonical cell-type specific gene regulation (left) and 3D genome regulation of common super-enhancer domains (right)