Fig. 2
From: InTAD: chromosome conformation guided analysis of enhancer target genes
a Structure of the InTAD package. b Simulated Hi-C map based on correlations between enhancers (x-axis) and genes (y-axis). TAD boundaries are indicated as dashed boxes. Marked is EPHB2, a validated ependymoma oncogene that correlates significantly with proximal and distal enhancers. c The correlation plot reveals co-activation of EPHB2 and a distal enhancer element located 200 kbp away from the transcription start site. Both, EPHB2 and the distal enhancer element, are specifically expressed in ependymomas of the molecular subgroup ST-EPN-RELA