decompTumor2Sig: identification of mutational signatures active in individual tumors

BMC Bioinformatics

Table 1 Mutation frequencies according to the probabilistic Shiraishi model of mutational signatures, exemplified by the 6+4∗4+2=24 parameters of the signature depicted in Fig. 2

Nucleotide change (central base)						Flanking bases					Transcription strand
C >A	C >G	C >T	T >A	T >C	T >G	Position	A	C	G	T	plus strand	minus strand
0.004	0.006	0.928	0.009	0.038	0.015	-2	0.237	0.228	0.293	0.242	0.493	0.507
						-1	0.362	0.220	0.279	0.139
						+1	0.131	0.053	0.764	0.052
						+2	0.232	0.277	0.277	0.214

Each parameter is the fraction of mutations caused by the mutational process which exhibit the respective characteristic. For instance, 92.8% of the changes are C >T and there is next to no transcriptional bias (compare to Fig. 2)

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