Fig. 1
From: Robustness of signal detection in cryo-electron microscopy via a bi-objective-function approach
Strategy and implementation of the BOF approach. a The BOF approach involves the use of two different objective functions. The first objective function deals with particle detection and the second one with particle verification. b The BOF approach used in this study combines FLC and MLE objective functions, which are not mathematically equivalent or correlated. User-determined templates/references are shown in the dashed boxes, designated with the nomenclature used throughout this manuscript