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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Multiscale modeling reveals angiogenesis-induced drug resistance in brain tumors and predicts a synergistic drug combination targeting EGFR and VEGFR pathways

Fig. 1

VEGFR signaling pathways in angiogenesis and the clinical associations of angiogenesis-related genes with the survival rates of glioma patients. a VEGFR signaling pathways in regulating endothelial cell survival, proliferation and angiogenesis. TAFs, such as VEGF, can bind to their receptor, VEGFR, and stimulate signaling pathways, including the PI3K and ERK pathways, which regulate endothelial cell survival, proliferation and migration during angiogenesis [23, 24]. VEGFR inhibitors (VEGFRI), such as Sorafenib and Sunitinib, can inhibit the VEGFR signaling pathway by blocking VEGF-VEGFR binding. b Prognostic significance of VEGF and VEGFR genes. Shown are survival rates of glioma patients in low- and high-risk groups predicted by the gene expression of VEGF and VEGFR. c Prognostic significance of genes in VEGFR signaling pathways. Shown are survival rates of glioma patients in low- and high-risk groups predicted by the expression levels of the genes in the VEGFR signaling pathway

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BMC Bioinformatics

ISSN: 1471-2105

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