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Fig. 6 | BMC Bioinformatics

Fig. 6

From: metamicrobiomeR: an R package for analysis of microbiome relative abundance data using zero-inflated beta GAMLSS and meta-analysis across studies using random effects models

Fig. 6

Meta-analysis for the difference in relative abundances of gut microbial KEGG pathways between male vs. female infants ≤6 months of age. Heatmap of log (odds ratio) (log (OR)) of relative abundances of gut microbial KEGG pathways at level 2 between male vs. female infants for each study and forest plot of pooled estimates of all studies with 95% confidence intervals (95% CI). All log (OR) estimates of each pathway from each study were from Generalized Additive Models for Location Scale and Shape (GAMLSS) with beta zero inflated family (BEZI) and were adjusted for feeding status and age of infants at sample collection. Pooled log (OR) estimates and 95%CI (forest plot) were from random effect meta-analysis models with inverse variance weighting and DerSimonian–Laird estimator for between-study variance based on the adjusted log (OR) estimates and corresponding standard errors of all included studies. Pathways with p-values for differential relative abundances < 0.05 are denoted with * and those with p-values < 0.0001 are denoted with **. Pooled log (OR) estimates with pooled p-values< 0.05 are in red and those with false discovery rate (FDR) adjusted pooled p-values < 0.1 are shown as triangles. KEGG: Kyoto Encyclopedia of Genes and Genomes; USA: United States of America; CA: California; FL: Florida; NC: North Carolina

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BMC Bioinformatics

ISSN: 1471-2105

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