Fig. 5
From: Adapting machine-learning algorithms to design gene circuits
Designing a robust biological counter using GeneNet. a Desired input/output function of a robust biological counter. b Simply integrating the input over time yields an analog counter with significant error, as shown by the spread in the input/output function (upper) and the relative errors between the two (lower). c GeneNet learns an “off-detector” network (left), with substantially reduced error rates (right). Inspection of gene dynamics (middle) shows that an excitable “digital” pulse of green activity is initiated at the end of the input pulse (shaded blue line)