Detailed prediction of protein sub-nuclear localization

BMC Bioinformatics

Table 4 Homologous protein pairs between four different organisms

	Overall	Both HB	HB/SVM	SVM	% of proteins (organism1)	% of proteins (organism2)
Human/Chimp	3663	2510 (68%)	58 (2%)	1095 (30%)	60%	62%
Human/Mouse	4316	2609 (60%)	67 (2%)	1640 (38%)	70%	50%
Human/Yeast	809	638 (79%)	50 (6%)	121 (15%)	13%	21%
Chimp/Mouse	4041	2667 (66%)	65 (2%)	1309 (32%)	65%	55%
Chimp/Yeast	776	608 (78%)	42 (6%)	126 (16%)	16%	20%
Mouse/Yeast	973	742 (76%)	50 (5%)	181 (19%)	13%	23%

We identified pairs of homologous proteins between human, chimp, mouse, and yeast. The second column in the table gives the overall numbers of pairs for these two organisms, the next three columns refer to pairs of proteins where both were predicted using homology-based inference, one was predicted with homology-based inference and the other one de novo, and both were predicted de novo. The last two columns give the percentage of proteins in the respective organisms for which a homolog was found

ISSN: 1471-2105