Balancing multiple objectives in conformation sampling to control decoy diversity in template-free protein structure prediction

Table 3 Comparison of Evo-Diverse to other algorithms on lowest energy via 2-sided Fisher’s and Barnard’s tests on the benchmark dataset. Top panel evaluates the null hypothesis that Evo-Diverse achieves similar performance on reaching the lowest energy, considering each of the other four algorithms in turn. The bottom panel evaluates the null hypothesis that Evo-Diverse achieves similar performance on reaching a lower lowest energy value in comparison to a particular algorithm, considering each of the four other algorithms in turn. Comparison of Evo-Diverse to other algorithms on lowest lRMSD via 2-sided Fisher’s and Barnard’s tests on the benchmark dataset. Top panel evaluates the null hypothesis that Evo-Diverse achieves similar performance on reaching the lowest lRMSD, considering each of the other four algorithms in turn. The bottom panel evaluates the null hypothesis that Evo-Diverse achieves similar performance on reaching a lower lowest lRMSD value in comparison to a particular algorithm, considering each of the four other algorithms in turn

ISSN: 1471-2105