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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Bioinformatics Resource Manager: a systems biology web tool for microRNA and omics data integration

Fig. 3

miRNA Target Prediction and Integration Workflow. The miRNA Targets query was utilized to (1) upload a list of 32 significant (q < 0.05) miRNA differentially expressed in human bronchial epithelial cells (HBEC) after exposure to benzo[a]pyrene (BAP), (2) identify potential miRNA gene targets from Microcosm, MicroRNA, TargetScan and miRTarBase resources, filtering for targets that are in at least 2 of the 4 databases, and (3) integrate the predicted gene targets with mRNA expression data collected in parallel in HBEC. The resulting miRNA-target gene interactions for the 3 most connected miRNAs are visualized as a network with significantly (p < 0.05) enriched biological function GO terms included for each subnetwork

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