Fig. 2

β-casein expressions predicted by the literature model and a modified version with competitive HER4 heterodimerization. Panels a and b show the time-integrated β-casein values (obtained by integrating the solutions of the nonlinear system of ODE at different time points over different time intervals - 12,24 and 48 h in three separate subpanels). The panels also show the instantaneous values (obtained by solving the nonlinear systems of ODEs at different time points) respectively as predicted by the literature models of JAK-STAT pathway for varying levels of NRG stimulations. Panels c and d show the same time-integrated and instantaneous levels of β-casein when competitive HER4 heterodimerization is included in the model. The time-integrated plot contains three subpanels showing the expression at three different time points (12, 24 and 48 h). The error bars are obtained by generating an ensemble of models by sampling over parameter space. The instantaneous plots are for 0–48 h range at five different NRG stimulations