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Fig. 6 | BMC Bioinformatics

Fig. 6

From: Time-dependent antagonist-agonist switching in receptor tyrosine kinase-mediated signaling

Fig. 6

First order (S1) and total effect (ST) Sobol Sensitivity Coefficients for the most sensitive species and kinetic rate constants for different model outputs. See Methods section for the definition of these sensitivity coefficients. a and b show the sensitivities concerning the species and parameters for absolute β-casein levels as output. c and d show sensitivities concerning the ratio of contributions to β-casein transcription by the JAK-dependent and JAK-independent parts of the pathway. e and f show the sensitivities concerning the time delay between STAT5 import into the nucleus and β-casein transcription. A sensitivity coefficient ST > > S1 indicates significant higher order contributions to the sensitivity

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