Fig. 4

Density plots of Spearman’s correlation coefficients (r_s) of gene-gene pairs following adjustment with five methods. (a) Density plot for r_s of false gene-gene pairs. (b) Density plot for r_s of true gene-gene pairs. We used 1796 true and 1179 false edges following adjustment with five methods and raw data for the GTEx Adipose Subcutaneous dataset. Data adjustment with hidden confounders, i.e., PEER and PCA-based covariates (colored in green and blue respectively) demonstrates a tendency toward zero mean of the correlation coefficients in the false and in the true gene-gene pairs