Fig. 5

Superimposing mTOR signaling subgraphs from KEGG and WikiPathways. A deeper analysis performed using PathMe Viewer to visualize mTOR signaling subgraphs can be seen highlighting interactions present in a KEGG only and b KEGG and WikiPathways. The contribution of WikiPathways onto the pathway found in KEGG is highlighted in orange. Neither agreements nor discrepancies in topology are noted between these subgraphs though there are overlapping genes (e.g., mTOR, RICTOR, EIF4EBP1, etc.). Instead, subgraph a) is complemented by additional interactions superimposed onto the network, as visualized in subgraph b)