Table 11 Melanoma case study. Effects of miRNAs, in terms of the score defined in “Simulation” Section, on gene mutations
From: MiRNA therapeutics based on logic circuits of biological pathways
miRNA | BRAF | RAF | NRAS | RAS | AKT | PI3K | MEK | CDK4/6 | Ranking |
|---|---|---|---|---|---|---|---|---|---|
Score obtained by a single miRNA | |||||||||
mir-124 | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | -1 → -1 | 0 → -1 | -8 |
mir-155 | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | -1 → -1 | 0 → -1 | -8 |
mir-497 | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | -1 → -1 | 0 → -1 | -8 |
mir-16 | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | -1 → -1 | 0 → -1 | -8 |
let-7b | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | -1 → -1 | 0 → -1 | -8 |
mir-302a | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | -1 → -1 | 0 → -1 | -8 |
let-7a | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → 0 | 0 → -1 | -1 → -1 | 0 → -1 | -7 |
mir-143 | -1 → -1 | -1 → -1 | 0 → 0 | 0 → -1 | 0 → -1 | 0 → -1 | -1 → -1 | 0 → 0 | -7 |
mir-7 | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | 0 → -1 | -1 → -1 | 0 → 0 | -7 |
mir-145 | -1 → -1 | -1 → -1 | 0 → -1 | 0 → 0 | 0 → 0 | 0 → 0 | -1 → -1 | 0 → -1 | -5 |
mir-429 | -1 → -1 | -1 → -1 | 0 → -1 | 0 → -1 | 0 → 0 | 0 → 0 | -1 → -1 | 0 → -1 | -5 |