Skip to main content

Table 11 Melanoma case study. Effects of miRNAs, in terms of the score defined in “Simulation” Section, on gene mutations

From: MiRNA therapeutics based on logic circuits of biological pathways

miRNA BRAF RAF NRAS RAS AKT PI3K MEK CDK4/6 Ranking
Score obtained by a single miRNA
mir-124 -1 → -1 -1 → -1 0 → -1 0 → -1 0 → -1 0 → -1 -1 → -1 0 → -1 -8
mir-155 -1 → -1 -1 → -1 0 → -1 0 → -1 0 → -1 0 → -1 -1 → -1 0 → -1 -8
mir-497 -1 → -1 -1 → -1 0 → -1 0 → -1 0 → -1 0 → -1 -1 → -1 0 → -1 -8
mir-16 -1 → -1 -1 → -1 0 → -1 0 → -1 0 → -1 0 → -1 -1 → -1 0 → -1 -8
let-7b -1 → -1 -1 → -1 0 → -1 0 → -1 0 → -1 0 → -1 -1 → -1 0 → -1 -8
mir-302a -1 → -1 -1 → -1 0 → -1 0 → -1 0 → -1 0 → -1 -1 → -1 0 → -1 -8
let-7a -1 → -1 -1 → -1 0 → -1 0 → -1 0 → 0 0 → -1 -1 → -1 0 → -1 -7
mir-143 -1 → -1 -1 → -1 0 → 0 0 → -1 0 → -1 0 → -1 -1 → -1 0 → 0 -7
mir-7 -1 → -1 -1 → -1 0 → -1 0 → -1 0 → -1 0 → -1 -1 → -1 0 → 0 -7
mir-145 -1 → -1 -1 → -1 0 → -1 0 → 0 0 → 0 0 → 0 -1 → -1 0 → -1 -5
mir-429 -1 → -1 -1 → -1 0 → -1 0 → -1 0 → 0 0 → 0 -1 → -1 0 → -1 -5