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Table 11 Melanoma case study. Effects of miRNAs, in terms of the score defined in “Simulation” Section, on gene mutations

From: MiRNA therapeutics based on logic circuits of biological pathways

miRNABRAFRAFNRASRASAKTPI3KMEKCDK4/6Ranking
Score obtained by a single miRNA
mir-124-1 → -1-1 → -10 → -10 → -10 → -10 → -1-1 → -10 → -1-8
mir-155-1 → -1-1 → -10 → -10 → -10 → -10 → -1-1 → -10 → -1-8
mir-497-1 → -1-1 → -10 → -10 → -10 → -10 → -1-1 → -10 → -1-8
mir-16-1 → -1-1 → -10 → -10 → -10 → -10 → -1-1 → -10 → -1-8
let-7b-1 → -1-1 → -10 → -10 → -10 → -10 → -1-1 → -10 → -1-8
mir-302a-1 → -1-1 → -10 → -10 → -10 → -10 → -1-1 → -10 → -1-8
let-7a-1 → -1-1 → -10 → -10 → -10 → 00 → -1-1 → -10 → -1-7
mir-143-1 → -1-1 → -10 → 00 → -10 → -10 → -1-1 → -10 → 0-7
mir-7-1 → -1-1 → -10 → -10 → -10 → -10 → -1-1 → -10 → 0-7
mir-145-1 → -1-1 → -10 → -10 → 00 → 00 → 0-1 → -10 → -1-5
mir-429-1 → -1-1 → -10 → -10 → -10 → 00 → 0-1 → -10 → -1-5