Table 4 A detailed view of effects of Everolimus/Trametinib on gene mutations, highlighting the circuit output without (second column) and with drug (third column), and the corresponding change in the score

EGFR

[1010000]

[0010111]

2 →-1

ERBB2

[1000000]

[0000111]

1 →-3

EML4-ALK

[1011000]

[0011111]

3 →-1

PTEN

[0000000]

[0000111]

0 →-3

KRAS

[1010000]

[0010111]

2 →-2

BRAF

[1000111]

[0000111]

-2 →-3

PIK3CA

[1000000]

[0000111]

1 →-3

AKT

[0000000]

[0000111]

0 →-3

MEK

[1000111]

[0000111]

-2 →-3

EML4-ALK+p16

[1111000]

[0011111]

4 →-1