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Table 6 NSCLC case study. Network scores obtained considering miRNAs acting on mutated gene targets. The table is organized considering the score obtained by a single miRNA, by a pair of miRNAs and by three miRNA, respectively. The last column, called ranking, represents the sum of the scores of a miRNA, or combination of miRNAs, corresponding to each gene target

From: MiRNA therapeutics based on logic circuits of biological pathways

miRNAEGFRERBB2EML4-ALKPTENKRASBRAFPIK3CAAKTMEKEML4-ALK+p16Ranking
Score obtained by a single miRNA
let-7g2 → -21 → -33 → -10 → -32 → -2-2 → -31 → -30 → -3-2 → -34 → -1-24
mir-15a2 → -21 → -33 → -10 → -32 → -2-2 → -31 → -30 → -3-2 → -34 → -1-24
mir-29a2 → -21 → -23 → 00 → -32 → -1-2 → -21 → -20 → -3-2 → -24 → 0-13
let-7c2 → -31 → 03 → 10 → 02 → 1-2 → -31 → 00 → 0-2 → -34 → 1-6
mir-3752 → -11 → -33 → 00 → 02 → -1-2 → -21 → 10 → 0-2 → -24 → 1-4
mir-27a2 → -31 → 13 → 30 → 02 → 2-2 → -21 → 10 → 0-2 → -24 → 4-3
mir-47892 → 11 → 03 → 10 → 02 → 1-2 → -31 → 00 → 0-2 → -34 → 1-2
mir-3302 → 21 → 13 → 30 → 02 → 2-2 → -11 → 10 → 0-2 → -14 → 4-2
mir-4972 → -31 → 13 → 30 → 02 → 2-2 → -21 → 10 → 0-2 → -24 → 30
mir-18a2 → 11 → 03 → 20 → 02 → 1-2 → -31 → 00 → 0-2 → -34 → 20
mir-193b2 → 11 → 03 → 20 → 02 → 1-2 → -31 → 00 → 0-2 → -34 → 20
mir-34a2 → 11 → 03 → 20 → 02 → 1-2 → -31 → 10 → 0-2 → -34 → 20
mir-27b2 → 21 → 13 → 30 → 02 → 2-2 → -21 → 10 → 0-2 → -24 → 40
mir-1422 → 11 → 03 → 20 → 02 → 1-2 → -21 → 00 → 0-2 → -24 → 22
mir-30e2 → -31 → 13 → 20 → 02 → 2-2 → -21 → 10 → 0-2 → -24 → 32
mir-1912 → 11 → 03 → 20 → 02 → 1-2 → -31 → 00 → 0-2 → -24 → 23
mir-3352 → 21 → 13 → 20 → 02 → 2-2 → -11 → 10 → 0-2 → -14 → 33
mir-172 → 21 → 13 → 20 → 02 → 2-2 → -21 → 10 → 0-2 → -24 → 35
mir-130b2 → 11 → 13 → 10 → 02 → 1-2 → -21 → 10 → 0-2 → -24 → 25
mir-47782 → 21 → 13 → 20 → 02 → 2-2 → -21 → 10 → 0-2 → -24 → 35
Score obtained by the combination of two miRNAs
let-7c/let-7g2 → -31 → -33 → -20 → -32 → -2-2 → -31 → -30 → -3-2 → -34 → -2-27
let-7g/mir-172 → -21 → -33 → -20 → -32 → -2-2 → -31 → -30 → -3-2 → -34 → -2-26
let-7g/mir-20a2 → -21 → -33 → -10 → -32 → -2-2 → -31 → -30 → -3-2 → -34 → -1-24
let-7g/miR-3352 → -11 → -23 → -10 → -22 → -1-2 → -21 → -20 → -2-2 → -24 → -1-16
mir-20a/mir-3352 → 21 → 13 → 20 → 02 → 2-2 → -11 → 10 → 0-2 → -14 → 33
mir-335/mir-172 → 21 → 13 → 20 → 02 → 2-2 → -11 → 10 → 0-2 → -14 → 33
mir-20a/mir-172 → 21 → 13 → 20 → 02 → 2-2 → -21 → 10 → 0-2 → -24 → 35
Score obtained by the combination of three miRNAs
let-7g/mir-17/mir-20a2 → -21 → -33 → -20 → -32 → -2-2 → -31 → -30 → -3-2 → -34 → -2-26