Table 6 NSCLC case study. Network scores obtained considering miRNAs acting on mutated gene targets. The table is organized considering the score obtained by a single miRNA, by a pair of miRNAs and by three miRNA, respectively. The last column, called ranking, represents the sum of the scores of a miRNA, or combination of miRNAs, corresponding to each gene target

let-7g

2 → -2

1 → -3

3 → -1

0 → -3

2 → -2

-2 → -3

1 → -3

0 → -3

-2 → -3

4 → -1

-24

mir-15a

2 → -2

1 → -3

3 → -1

0 → -3

2 → -2

-2 → -3

1 → -3

0 → -3

-2 → -3

4 → -1

-24

mir-29a

2 → -2

1 → -2

3 → 0

0 → -3

2 → -1

-2 → -2

1 → -2

0 → -3

-2 → -2

4 → 0

-13

let-7c

2 → -3

1 → 0

3 → 1

0 → 0

2 → 1

-2 → -3

1 → 0

0 → 0

-2 → -3

4 → 1

-6

mir-375

2 → -1

1 → -3

3 → 0

0 → 0

2 → -1

-2 → -2

1 → 1

0 → 0

-2 → -2

4 → 1

-4

mir-27a

2 → -3

1 → 1

3 → 3

0 → 0

2 → 2

-2 → -2

1 → 1

0 → 0

-2 → -2

4 → 4

-3

mir-4789

2 → 1

1 → 0

3 → 1

0 → 0

2 → 1

-2 → -3

1 → 0

0 → 0

-2 → -3

4 → 1

-2

mir-330

2 → 2

1 → 1

3 → 3

0 → 0

2 → 2

-2 → -1

1 → 1

0 → 0

-2 → -1

4 → 4

-2

mir-497

2 → -3

1 → 1

3 → 3

0 → 0

2 → 2

-2 → -2

1 → 1

0 → 0

-2 → -2

4 → 3

0

mir-18a

2 → 1

1 → 0

3 → 2

0 → 0

2 → 1

-2 → -3

1 → 0

0 → 0

-2 → -3

4 → 2

0

mir-193b

2 → 1

1 → 0

3 → 2

0 → 0

2 → 1

-2 → -3

1 → 0

0 → 0

-2 → -3

4 → 2

0

mir-34a

2 → 1

1 → 0

3 → 2

0 → 0

2 → 1

-2 → -3

1 → 1

0 → 0

-2 → -3

4 → 2

0

mir-27b

2 → 2

1 → 1

3 → 3

0 → 0

2 → 2

-2 → -2

1 → 1

0 → 0

-2 → -2

4 → 4

0

mir-142

2 → 1

1 → 0

3 → 2

0 → 0

2 → 1

-2 → -2

1 → 0

0 → 0

-2 → -2

4 → 2

2

mir-30e

2 → -3

1 → 1

3 → 2

0 → 0

2 → 2

-2 → -2

1 → 1

0 → 0

-2 → -2

4 → 3

2

mir-191

2 → 1

1 → 0

3 → 2

0 → 0

2 → 1

-2 → -3

1 → 0

0 → 0

-2 → -2

4 → 2

3

mir-335

2 → 2

1 → 1

3 → 2

0 → 0

2 → 2

-2 → -1

1 → 1

0 → 0

-2 → -1

4 → 3

3

mir-17

2 → 2

1 → 1

3 → 2

0 → 0

2 → 2

-2 → -2

1 → 1

0 → 0

-2 → -2

4 → 3

5

mir-130b

2 → 1

1 → 1

3 → 1

0 → 0

2 → 1

-2 → -2

1 → 1

0 → 0

-2 → -2

4 → 2

5

mir-4778

2 → 2

1 → 1

3 → 2

0 → 0

2 → 2

-2 → -2

1 → 1

0 → 0

-2 → -2

4 → 3

5

Score obtained by the combination of two miRNAs

let-7c/let-7g

2 → -3

1 → -3

3 → -2

0 → -3

2 → -2

-2 → -3

1 → -3

0 → -3

-2 → -3

4 → -2

-27

let-7g/mir-17

2 → -2

1 → -3

3 → -2

0 → -3

2 → -2

-2 → -3

1 → -3

0 → -3

-2 → -3

4 → -2

-26

let-7g/mir-20a

2 → -2

1 → -3

3 → -1

0 → -3

2 → -2

-2 → -3

1 → -3

0 → -3

-2 → -3

4 → -1

-24

let-7g/miR-335

2 → -1

1 → -2

3 → -1

0 → -2

2 → -1

-2 → -2

1 → -2

0 → -2

-2 → -2

4 → -1

-16

mir-20a/mir-335

2 → 2

1 → 1

3 → 2

0 → 0

2 → 2

-2 → -1

1 → 1

0 → 0

-2 → -1

4 → 3

3

mir-335/mir-17

2 → 2

1 → 1

3 → 2

0 → 0

2 → 2

-2 → -1

1 → 1

0 → 0

-2 → -1

4 → 3

3

mir-20a/mir-17

2 → 2

1 → 1

3 → 2

0 → 0

2 → 2

-2 → -2

1 → 1

0 → 0

-2 → -2

4 → 3

5

Score obtained by the combination of three miRNAs

let-7g/mir-17/mir-20a

2 → -2

1 → -3

3 → -2

0 → -3

2 → -2

-2 → -3

1 → -3

0 → -3

-2 → -3

4 → -2

-26