Table 5 Composition data sets used in this study
Data Set | Reference | Total variants | Number of proteins | Stabilizing (ΔΔG ≥ 0) | Destabilizing (ΔΔG < 0) |
|---|---|---|---|---|---|
VariBench | Yang et al. [23] | 1564 | 99 | 436 | 1128 |
Broom | Broom et al. [33] | 605 | 58 | 147 | 458 |
S2648 | Dehouck et al. [11] | 2648 | 132 | 602 | 2046 |
P53 | Pires et al. [14] | 42 | 1 | 11 | 31 |
Myoglobin | Kepp et al. [34] | 134 | 1 | 38 | 96 |
Ssym | Pucci et al. [28] | 684 | 15 wild-type | 342 | 342 |
PTmul | From ProTherm | 914 | 90 | 310 | 604 |