AutoCryoPicker: an unsupervised learning approach for fully automated single particle picking in Cryo-EM images

BMC Bioinformatics

Table 3 Statistical evaluation AutoCryoPicker and EMAN2 performance using the Apoferritin and KLH images

Cryo-EM images	Particle Shape	Total Particles Number	AutoCryoPicker			EMAN2
Cryo-EM images	Particle Shape	Total Particles Number	TP	FN	FP	TP	FN	FP
Apoferritin Image 1	Top-View	151	148	3	2	84	67	0
Apoferritin Image 2	Top-View	160	159	1	5	83	76	1
KLH image 1	Top-View	17	14	3	0	8	9	11
KLH image 2	Top-View	7	7	0	0	3	4	10
KLH image 1	Side-View	24	8	15	0	N/A	N/A	N/A
KLH image 2	Side-View	14	6	8	0	N/A	N/A	N/A

The table reports TP: True Positive picking results where the correct particles are picked, FN: False Negative picking results where some good particles are missed, FP: False Positive picking results where the incorrect particles (other objects such as background or artificial objects) are picked as particles

ISSN: 1471-2105