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Fig. 7 | BMC Bioinformatics

Fig. 7

From: Prediction of regulatory targets of alternative isoforms of the epidermal growth factor receptor in a glioblastoma cell line

Fig. 7

Probability density plot of the normal distributions of TRP. For group a we mark the logarithmic expression values x1,…,x6 of TPR with black points, which are colored according to Fig. 6a, and assume that all six logarithmic expression levels stem from the same normal distribution. In black, we plot the probability density of this normal distribution with mean and standard deviation equal to μ and σ of the six logarithmic expression levels. For groups b - d we assume that all six logarithmic expression levels stem from a mixture of two normal distributions with independent means μ0 and μ1 and one pooled standard deviation σ. We mark the logarithmic expression values x1,…,x6 of TPR with points which are colored according to indicator variables from Fig. 6 g=0 in red and g=1 in blue and we plot the probability densities of the two normal distributions in red and blue, respectively. For group b we assume that the logarithmic expression levels x1, x3, and x5 stem from the normal distribution with mean μ0 (red) and x2, x4, and x6 from the normal distribution with mean μ1 (blue). For gene group c we assume that the logarithmic expression levels x1, x3, x5, and x6 stem from the normal distribution with mean μ0 (red) and x2 and x4 from the normal distribution with mean μ1 (blue). For group d we assume that the logarithmic expression levels x1, x3, x4, x5, and x6 stem from the normal distribution with mean μ0 (red) and x2 stem from the normal distribution with mean μ1 (blue)

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