Fig. 8
From: A model of pulldown alignments from SssI-treated DNA improves DNA methylation prediction
Methylation predictions for an external MBD/WGBS data set. To act as an external data set to test the effectiveness of our MBD pulldown model, we use the WGBS and MBD pulldown data from [14]. We consider all 100 bp windows on chromosome 7 with at least 75% mappable bases and at least 33 reads in WGBS coverage, the same specifications as considered by Riebler et al.. Each plot point in the main graph corresponds to a 5 percentile increment in the minimum modeled SssI Control coverage, yiΛ, from the 0th percentile to the 95th percentile, and the AUC is calculated for each BayMeth configuration on all windows that meet the minimum threshold. ROC curves analyzing the windows with the top quartiles in yiΛ are plotted above, corresponding to the cutoff identified in the gray boxes on the main graph