Fig. 1

Similarity between COSMIC signatures. a Pairwise cosine similarity of the 30 COSMIC signatures. Co-linear signatures have a similarity of 1, and orthogonal signatures a similarity of 0. Signatures 5 & 16 have a similarity higher than 0.9. b Computed cosine similarity of each signature with the profile that was constructed by trying to reconstruct each signature with the 29 others. The signatures are ordered by decreasing similarity to their reconstructed profile