Fig. 6
From: Game of neutrophils: modeling the balance between apoptosis and necrosis
Data Parameter Space (m, bApoptosis, α). Each point in the plot corresponds to the combination of parameters that satisfies the data. This 3-dimensional parameter data space can be better visualized via an interactive plot, which we have uploaded to the following link for (a) and (b) respectively: https://github.com/avpresbitero/EGTN (2) and (3). The colors are chosen only to add visual depth to the plot, where purple to yellow corresponds to increasing values of α. The evolutionary stable percentages of neutrophils correspond to lower benefits of apoptosis and costs of necrosis when the costs of remaining ITMs become threatening to the system. Stronger resolving power of ITMs, or higher values of m, correspond to narrower range and lower benefits of apoptosis and costs of necrosis in the data parameter space. Despite making necrosis detrimental to the system, nature balances the collective effect of the intrinsic property of neutrophils, cost of necrosis and benefit of apoptosis. Nature could have also made the anti-inflammatory benefits of apoptosis more effective especially when the presence of remaining ITMs becomes increasingly threatening to the organism