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Fig. 4 | BMC Bioinformatics

Fig. 4

From: Mathematical model of hypoxia and tumor signaling interplay reveals the importance of hypoxia and cell-to-cell variability in tumor growth inhibition

Fig. 4

Hypoxia can induce an increase, decrease, or no change in Akt activity. a Two simulation cases showing differential steady-state pAkt responses to step reduction in O2 levels of various severity (normoxia = 100%). The time course for the pAkt responses to 0.5% O2 is illustrated in the insert, where x-axis is time and y-axis is the level of phosphorylated ERK. The solid bar above the line trace indicates when 0.5% O2 was applied in the simulation. b Histograms summarizing the distribution of pAkt responses from all 20,000 simulation cases at various degrees of hypoxia. c Decision tree showing that pAkt/tAkt ratio is the key factor deciding how pAkt response to hypoxia (0.5% O2), with pPI3K, EEGFR (the complex of EGF and its receptor) and VVR_P_PI3K (the complex of PI3K and the phosphorylated dimer of VVEGFR) also playing contributing roles

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BMC Bioinformatics

ISSN: 1471-2105

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