Table 1 Data for diseases, disease-protein relationships, and protein-protein interactions, and literature for comorbidity analysis: the number in parentheses indicates the amount of data originating from the respective sources. See also Additional file 1: Appendix A and C
From: The translational network for metabolic disease – from protein interaction to disease co-occurrence
Metabolic diseases | Disease-protein relationship | Protein-protein interaction | Comorbidity analysis | |
|---|---|---|---|---|
Data Sources | MeSH The Medical Subject Headings | CTD (7624) ver. 2014/07/11 Comparative Toxicogenomics Database, www.ctdbase.org/ GAD (34,773) ver.2013/07/16 Genetic Association Database, www.geneticassociationdb.nih.gov/ OMIM (4078) ver. 2014/03/10 Online Mendelian Inheritance in Man, www.omim.org/ PharmGKB (6610) ver. 2015/07/20 The Pharmacogenomics Knowledge Base, www.pharmgkb.org/ TTD (395) ver. 2013/07/04 Therapeutic Target Database, www.bidd.nus.edu.sg/group/cjttd/ | DIP (773) ver. 2014/10/10 Database of Interacting Proteins, www.dip.doebi.ucla.edu/dip/Main.cgi Entrez Gene (58,778) ver. 2014/07/20 www.jura.wi.mit.edu/entrez_gene/ MINT (736) ver. 2014/07/08 Molecular Interaction Database, www.mint.bio.uniroma2.it/mint/ PharmGKB (507) ver. 2014/07/20 The Pharmacogenomics Knowledge Base, www.pharmgkb.org/ | PubMed Literature US National Library of Medicine National Institutes of Health |
Number of Data | 181 out of 302 metabolic diseases | 53,480 relations between 2411 diseases and 7733 proteins | 60,794 interactions of 15,281 proteins | 62 pairs of 55 diseases |