Fig. 1
From: Drug repositioning based on individual bi-random walks on a heterogeneous network
A heterogeneous network consists of drug similarity network \(\mathbf {S}_{r} \in \mathbb {R}^{n_{r} \times n_{r}}\) with nr drugs, disease similarity network \(\mathbf {S}_{d} \in \mathbb {R}^{n_{d} \times n_{d}}\) with nd diseases, drug-disease association network \(\mathbf {W}_{rd} \in \mathbb {R}^{n_{r} \times n_{d}}\) between nr drugs and nd diseases. Each circle represents a drug, each hexagon represents a disease. In the drug (disease) similarity network, the solid edges describe the similarities of drug (disease) pairs. In the drug-disease association network, the solid edges indicate the known drug-disease associations, and the dashed edges indicate the potential associations between drugs and diseases, which are the new indications of drugs