Fig. 2
From: RNA 3D structure prediction guided by independent folding of homologous sequences
The workflow implemented as EvoClustRNA - as an example of a structure prediction of the ZMP Riboswitch (RNA-Puzzle 13). (1) Sequences of homologs are found for the target sequence, and an RNA alignment is prepared. (2) Using Rosetta and/or SimRNA structural models for all sequences are generated. (3) The conserved regions are extracted and clustered. (4) The final prediction of the method is the model containing the most commonly preserved structural arrangements in the set of homologs