Fig. 3
From: AMON: annotation of metabolite origins via networks to integrate microbiome and metabolome data
Enrichment of pathways and a single enriched pathway colored with metabolite origin. a A heatmap showing the p-values associated with a pathway enrichment analysis with KEGG pathways. The first column is p-values for enrichment of KEGG pathways in compounds that were detected via untargeted LC/MS of plasma and we predict could be generated by members of the fecal microbiome. The second column is the same but for compounds that we predicted could have been generated by the human host. b This pathway map is colored by putative origin of the compound, which are circles, and presence of the reaction, which are rectangles. Dark blue is a compound or gene with a bacterial origin, yellow is a compound or gene with a human origin, orange outlined compounds are detected in the metabolomics. Circles or rectangles could be of human or bacterial origin