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Table 4 Top 25 novel DDIs predicted by the proposed method DDI-PULearn

From: DDI-PULearn: a positive-unlabeled learning method for large-scale prediction of drug-drug interactions

RankDrug1Drug1 NameDrug2Drug2 NameScore
1DB01137LevofloxacinDB01182Propafenone1
2DB00512VancomycinDB00704Naltrexone1
3DB00704NaltrexoneDB00783Estradiol1
4DB00773EtoposideDB00783Estradiol1
5DB01137LevofloxacinDB00704Naltrexone1
6DB00635PrednisoneDB00704Naltrexone1
7DB00295MorphineDB01037Selegiline0.975
8DB01050IbuprofenDB00712Flurbiprofen0.975
9DB00218MoxifloxacinDB00328Indomethacin0.975
10DB00213PantoprazoleDB01189Desflurane0.975
11DB00586DiclofenacDB01037Selegiline0.975
12DB00398SorafenibDB00445Epirubicin0.975
13DB00724ImiquimodDB00331Metformin0.975
14DB00203SildenafilDB00457Prazosin0.975
15DB00999HydrochlorothiazideDB00880Chlorothiazide0.975
16DB00635PrednisoneDB00324Fluorometholone0.975
17DB00704NaltrexoneDB00327Hydromorphone0.975
18DB00295MorphineDB00704Naltrexone0.975
19DB00813FentanylDB01232Saquinavir0.975
20DB00624TestosteroneDB00959Methylprednisolone0.95
21DB00959MethylprednisoloneDB00550Propylthiouracil0.95
22DB01193AcebutololDB00264Metoprolol0.95
23DB00295MorphineDB00674Galantamine0.95
24DB01137LevofloxacinDB00323Tolcapone0.95
25DB00591Fluocinolone AcetonideDB00641Simvastatin0.95
  1. (DDIs which are confirmed in DrugBank are highlighted in bold font.)