Fig. 6

Example of structural alignment between triad pairs. In this case, Proteus suggested mutations for the sites C19-I35 (blue sticks) of the crystal structure of tobacco etch virus protease (PDB ID: 1q31). Proteus detected overlap with RMSD of 0.46 between the C19-I35 residues and triad pairs formed between S94-Y190 (green sticks) of a membrane protein (PDB ID: 1iiw). For this reason, Proteus suggested the mutation C19S-I35Y