Fig. 6
From: DiNeR: a Differential graphical model for analysis of co-regulation Network Rewiring
a Summary of the proximal to distal change of binding peaks from GM12878 to K562. b Cumulative density of distance of BRCA1 peaks to the nearest TSS in both GM12878 and K562 showcases a dramatic shift in binding profiles between disease and control. c Survival analysis in AML using BRCA1 regulatory activity as a prognosis marker, showcasing disrupted BRCA1 regulatory activity results in a worse prognosis. Group 1 includes patients with above average regulatory activity of BRCA1 while group 2 contains those with below average regulatory activity