NEDD: a network embedding based method for predicting drug-disease associations

BMC Bioinformatics

Table 1 Associations with the highest prediction scores

Rank	Drug		Disease		References
Rank	ID (DrugBank)	Name	ID (OMIM)	Name	References
1	DB01202	Levetiracetam	208,700	ATAXIA WITH MYOCLONIC EPILEPSY AND PRESENILE DEMENTIA	[35]
2	DB01181	Ifosfamide	267,730	RETICULUM CELL SARCOMA	–
3	DB00937	Diethylpropion	303,110	CHOROIDEREMIA, DEAFNESS, AND MENTAL RETARDATION	–
4	DB00584	Enalapril	161,900	RENAL FAILURE, PROGRESSIVE, WITH HYPERTENSION; RFH1	[36]
5	DB00444	Teniposide	276,300	MISMATCH REPAIR CANCER SYNDROME; MMRCS	–
6	DB01070	Dihydrotachysterol	277,440	VITAMIN D-DEPENDENT RICKETS, TYPE 2A; VDDR2A	[37]
7	DB00176	Fluvoxamine	131,300	CAMURATI-ENGELMANN DISEASE; CAEND	–
8	DB00710	Ibandronate	167,320	INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA 1; IBMPFD1	[38]
9	DB00710	Ibandronate	602,080	PAGET DISEASE OF BONE 2, EARLY-ONSET; PDB2	[38]
10	DB00282	Pamidronic acid	602,080	PAGET DISEASE OF BONE 2, EARLY-ONSET; PDB2	[39]
11	DB01551	Dihydrocodeine	147,530	INSENSITIVITY TO PAIN WITH HYPERPLASTIC MYELINOPATHY	–
12	DB00500	Tolmetin	147,530	INSENSITIVITY TO PAIN WITH HYPERPLASTIC MYELINOPATHY	–
13	DB00136	Calcitriol	241,519	HYPOPHOSPHATEMIA, RENAL, WITH INTRACEREBRAL CALCIFICATIONS	[40]
14	DB00214	Torasemide	256,370	NEPHROTIC SYNDROME, TYPE 4; NPHS4	[41]
15	DB01120	Gliclazide	600,496	MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3; MODY3	[42]

ISSN: 1471-2105