Fig. 4

Examination of species-specific differences in mouse and human immune systems. a Each difference between mouse and human immune components described in Janeway was recorded and classified into one of four categories. The coloring of each category is consistent across 4a, 4b, and 4d. b Bar graph showing the frequency of each difference category. c A network visualization of ImmunoGlobe highlighting the concentration of species-specific differences in immune cells. Intensity of node color reflects the total number of differences affecting that node’s function in the immune system. d A visualization of the immune processes and specific nodes that differ between mouse and human immune systems. The boxes represent immune processes and are sized according to the number of species-specific immune differences affecting that process. Nodes are sized to reflect the number of differences affecting each node, and are positioned according to the process in which its differences are involved. The coloring of each node shows which proportion of differences affecting that node belong to each of the four categories described in (a)