Table 1 Comparison of centrality scores of essential proteins versus non-essential proteins
From: Comprehensive host-pathogen protein-protein interaction network analysis
Centrality | Essential Proteins | Non-Essential Proteins | t-score | p-value | ||
|---|---|---|---|---|---|---|
Mean | Standard Error | Mean | Standard Error | |||
Degree | 38.41 | 0.84 | 20.12 | 0.33 | 20.14 | 2.7e-88 |
Radiality | 0.76 | 0.0004 | 0.73 | 0.0003 | 38.68 | 9.4e-311 |
Closeness | 0.32 | 0.0004 | 0.3 | 0.0002 | 40.7 | 1.2e-313 |
Betweenness | 0.0002 | 0.00002 | 0.00007 | 0.000003 | 6.45 | 1.2e-10 |
Clustering Coefficient | 0.095 | 0.0017 | 0.082 | 0.0014 | 5.78 | 7.9e-09 |
Average Shortest Path | 3.15 | 0.004 | 3.36 | 0.003 | −38.68 | 9.4e-311 |
Topological Coefficient | 0.096 | 0.0015 | 0.138 | 0.0013 | −20.55 | 1.1e-92 |
Neighborhood Connectivity | 233.93 | 4.84 | 206.64 | 3.28 | 4.66 | 3.1e-06 |
Eigen vector centrality | 0.03 | 0.0006 | 0.01 | 0.0002 | 29.02 | 1.8e-176 |
Page rank centrality | 0.0007 | 0.00002 | 0.0004 | 0.000005 | 15.06 | 1.3e-50 |