Table 6 Top 20 predicted DDIs by DPDDI

1

Doxycycline

Bleomycin

DrugBank

Doxycycline may decrease the excretion rate of Bleomycin which could result in a higher serum level.

2

Doxycycline

Rifapentine

N/A

N/A

3

Doxycycline

Fusidic acid

N/A

N/A

4

Pramipexole

Paroxetine

DrugBank

Paroxetine may increase the sedative activities of Pramipexole.

5

Luliconazole

Doxycycline

N/A

N/A

6

Netupitant

Doxycycline

DrugBank

The metabolism of Netupitant can be decreased when combined with Doxycycline.

7

Tenoxicam

Minocycline

N/A

N/A

8

Etoperidone

Tenoxicam

DrugBank

Tenoxicam may decrease the excretion rate of Etoperidone which could result in a higher serum level.

9

Pramipexole

Minocycline

N/A

N/A

10

Ropinirole

Pramipexole

DrugBank

Ropinirole may increase the sedative activities of Pramipexole.

11

Minocycline

Ropinirole

DrugBank

Minocycline may increase the central nervous system depressant (CNS depressant) activities of Ropinirole.

12

Bleomycin

Doxycycline

DrugBank

Doxycycline may decrease the excretion rate of Bleomycin which could result in a higher serum level.

13

Pramipexole

Metyrosine

drugs.com

Using metyroSINE together with pramipexole may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating.

14

Osimertinib

Doxycycline

DrugBank

The metabolism of Osimertinib can be decreased when combined with Doxycycline.

15

Dronabinol

Pramipexole

DrugBank

Dronabinol may increase the sedative activities of Pramipexole.

16

Rufinamide

Tenoxicam

N/A

N/A

17

Phenobarbital

Pramipexole

drugs.com

Using PHENobarbital together with pramipexole may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating.

18

Bleomycin

Mitotane

N/A

N/A

19

Fosaprepitant

Doxycycline

DrugBank

The metabolism of Fosaprepitant can be decreased when combined with Doxycycline.

20

Duloxetine

Rufinamide

drugs.com

Using DULoxetine together with rufinamide may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating.