Fig. 3

a Effect of the mediators exclusively expressed in brain on the downstream genes. The forest plot represents 95% confidence intervals of the effect size in downstream gene transcription by the different mediator gene, red: mean effect size for SCZ-cases, blue: mean effect size for controls. Non-significant effect corresponds to loss of mediators. b Upstream genes and downstream genes for the mediators (GABRA2, LRRTM2, PPM1E) and their causal effects in controls. The arrows represent transcription activation (positive effect size). The line with capped end represents transcriptional repression (negative effect size). In cyan is the gene reported as SCZ-associated gene in previous studies. For all interactions, the estimate of the effect size (Est) and standard deviation (Std) are shown