Fig. 1

The animated display. Panel A shows the sliding window of the animated display in translation mode. Key features of the animated display are labelled such as the translated peptide sequences and the frame in which they occur, the presence of start and stop codons are highlighted in green and red, respectively. The location of the audio play-head is represented to coincide with the peptidyl-transferase centre of the ribosome. The sonified audio is generated as the SARS-CoV-2 genome sequence passes through the play-head. The direction in which the ribosome moves relative to the RNA sequence is indicated. Panel B shows the animated display in transcription mode. The newly synthesised minus RNA strand is shown below the genome sequence with the 3′ extended nucleotide shown in the play-head. The direction in which the replicase protein complex moves in relation to genome sequence is indicated