Fig. 3

The visualization and biological explanation of C3 module for asthma. a Subgraph of the full interactome showing the connections among the asthma DAPs. Asthma DAPs are scattered within 83 SCCs in the interactome (shown in shades). The colors of the nodes indicate the source of each seed. There are five sources: (i) Literature; (ii) GWAS; (iii) OMIM; (iv) MeSH; (v) Pathways. b C3 module of Asthma. There are 111 seeds (red nodes) and 61 C3 proteins (grey nodes) in the module. The interaction between them is also indicated in the module. c Biological interpretation of C3 module for asthma. We consider three verification datasets: (i) Gene expression of asthma-specific compiled from eight sources; (ii) GO term similarity (BP); (iii) Disgenet. Enrichment shows the fraction of C3 (Deep red line), DIAMOnD (green line), seeds (short dotted red line) and random (Dotted blue line) proteins in different validation datasets, statistical significance shows the corresponding statistical test p values, which are derived from the hypergeometric. (D) Functional annotation of GO term (BP) and KEGG pathway (p value < 0.01) of C3 proteins using DAVID. The pink bar indicates the − log₁₀ operation on the enriched p value