Fig. 4
From: Signaling pathways have an inherent need for noise to acquire information
Information, output range and noise in a pair of reversible binding interactions. Contour plots of a noise, b output range, and c information acquisition in the receptor-signal-DNAbs complex (RSD) as a function of the affinities between both the receptor and the signal (KeqR,S), and the receptor-signal complex with the downstream molecule (KeqRS,D). Red-dashed rectangles circumscribe biologically sensible receptor-signal DNA affinities ([10−8 M, 10−13 M]) and receptor signal affinities ([10−6 M, 10−9 M]). White-dashed rectangles delineate the region of maximal information acquisition at the receptor-signal-DNAbs level. Acquired information, output range and noise are plotted from minimally to maximally observed values, color-coded as indicated by the color bar