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Table 1 Over-representation analysis of disease pairs with overlapping gene(s)

From: LAMP: disease classification derived from layered assessment on modules and pathways in the human gene network

  With overlapping gene(s) All Fisher test
In the same LAMP category 1593 170,977 p value < 0.001
Not in the same LAMP category 3036 1,317,698
In the same KEGG category 2707 229,497 p value < 0.001
Not in the same KEGG category 1922 125,9178
  1. 1726 diseases make up 1488675 pairs, of which 4629 pairs with overlapping gene(s). The number of disease pairs in LAMP and KEGG categories is listed. In Fisher test p value < 0.001, which implies that disease pairs with overlapping gene(s) are more likely to belong to the same LAMP or KEGG category. Meanwhile, overlapping disease genes unnecessarily lead to the same category in LAMP and KEGG