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Table 1 Over-representation analysis of disease pairs with overlapping gene(s)

From: LAMP: disease classification derived from layered assessment on modules and pathways in the human gene network

 

With overlapping gene(s)

All

Fisher test

In the same LAMP category

1593

170,977

p value < 0.001

Not in the same LAMP category

3036

1,317,698

In the same KEGG category

2707

229,497

p value < 0.001

Not in the same KEGG category

1922

125,9178

  1. 1726 diseases make up 1488675 pairs, of which 4629 pairs with overlapping gene(s). The number of disease pairs in LAMP and KEGG categories is listed. In Fisher test p value < 0.001, which implies that disease pairs with overlapping gene(s) are more likely to belong to the same LAMP or KEGG category. Meanwhile, overlapping disease genes unnecessarily lead to the same category in LAMP and KEGG
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BMC Bioinformatics

ISSN: 1471-2105

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