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Table 5 Transmembrane topology prediction performance on the training dataset

From: Integrative approach for detecting membrane proteins

Tool

Sensitivity

Specificity

Accuracy

MCC

HMMTOP

72.71

84.60

78.73

0.5777

TOPCONS2

69.86

99.77

85.01

0.7318

TMHMM

68.61

97.14

83.06

0.6878

PRED-TMBB2

41.73

55.48

48.70

− 0.0281

  1. TOPCONS2, highlighted in italics, is the tool that achieved the highest MCC and is the method utilized in TooT-M