Fig. 3

MiBiOmics multi-omics integration. MiBiOmics visualizations (multi-omics integration section) from the analysis of the The Cancer Genome Atlas Network [14] breast cancer TCGA datasets. a A multiple co-inertia plot integrating 3 omics layers and extracted miRNA, mRNA and protein drivers. In the MiBiOmics 3-layers co-inertia analysis representation, each sample is represented by a triangle: the three vertices are the positions of the sample in each ordination space of the 3-layers co-inertia analysis. The edges linking these vertices indicate how each layer of the sample’s covariate in each ordination space [27]. b Hive plot displaying modules of each omics network and their associations. Red edges represent positive associations, and blue edges negative associations. Edge color intensity reflects the correlation strength. c Bipartite network between mRNA features of the red mRNA module and miRNA features of the red miRNA module (Spearman Correlation > 0.35). When the user selects two modules of interest, variables belonging to both modules are correlated 2-by-2 and variables correlating significantly above a correlation threshold selected by the user are linked together with an edge