Fig. 1

Schematic diagram of the benchmarking framework used in this study. The benchmarking workflow written in YAML format consists of four main steps in which the software tool employed in each step is dockerized and indicated within parentheses. The details of the Docker images for these software tools, which are available in Docker Hub, are specified in the “Methods” section. This benchmarking workflow was executed using Loom, an in-house workflow engine. The inputs to the benchmarking workflow are depicted on the left and the outputs are on the right with the red arrows from the outputs to workflow steps indicating the dependency of the output of that step with another step. The steps in the benchmarking workflow are repeated for each stratified region of interest provided