Fig. 5

TopoFilter performance for the yeast TOR signaling model. a Number of identified viable projections (submodels of the root model) for rank 1 (blue) and 2 (red) exhaustive searches with balanced enumeration strategy, depending on the number of allowed model evaluations in each (re-)sampling step, n. Symbols indicate number of workers in parallelized runs (inset). b Number of viable projection divided by the number of times the parameter space sampling was carried out when the number of samples left after projecting and filtering was smaller than the user-defined threshold (here: 1/20 of the number of evaluations per sample); symbols are as in (a). c Run time as a function of number of parallel processes for n=10² (blue), n=10³ (red), and n=10⁴ (orange); symbols indicate the enumeration level (inset). The dashed lines give references for a slope of -1. Regression lines (and their standard prediction errors; shaded) were computed for groups per exhaustive search rank r (a,b), or per number of function evaluations n (c)