Fig. 2
From: Detection of suspicious interactions of spiking covariates in methylation data
Top 6 of the reverse negative or negation CpG sites of the data set E-GEOD-55454. The order was determined by the effect deviation between the coefficients from two linear regressions, one associated with all data included and one with exclusion of the spike associated data. In contrast to E-GEOD-54643 the spike at right decreases the regression line. Without the spike the regression effect would be positive, including the spike at right the regression effect becomes negative. Again, a biologist has to decide, if the CpG sites are biological connected or can be seen as outlier. Table 3 shows the position and genes nearby of the CpG sites